IP International Journal of Aesthetic and Health Rejuvenation

A study of the development of aesthetic analogue scale for deep brain stimulus coding to rejuvenate parkinson`s motor functioning

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Article Type : Original Article

Author Details: Venkateshwarla Rama Raju*

Volume : 3

Issue : 4

Online ISSN : XXXX

Print ISSN : XXXX

Article First Page : 111

Article End Page : 116

Abstract

Subthalamic-nuclei deep brain stimulation (STN-DBS) is a therapeutic surgical technique for advanced idiopathic Parkinson`s. The technique engrosses or rivets implanting the electrode into the brain. Besides booting process for precisely embedding innocuous tiny micro-wires (the microelectrodes) via DBS surgical implantation procedure, efficient coding (i.e., programming) is most significant dynamic and flexible factor for a successful diagnosis and clinical outcome. Whilst, DBS procedure is well developed for regulating the neuro stimulations, its encoding remains cumbersome and source limit (restraint control, energy in battery is a constrained resource). While, kinematic and neuronal bio markers (bio signals) have been investigated as potential feed-back mechanism for adaptive closed loop DBS devices (ACL-DBSD) of late, albeit, there is an emerging need for coding approaches for procedures to adjust the stimulus parameters and electrode technical-specifications and analogous configurations in fact precisely. In this study, an aesthetic analogue scale (AAS) for a real-time adjustment of stimulus parameters is tested visually. The stimulus parameters: stimulus-intensity, stimulus-contact and amplitude pulse-width in Parkinson subjects amid DBS-subthalamic-nuclei were optimized based on the patient’s subjective AAS evaluation (score). Murkowski distance (Mk<sub>d</sub>) was computed to contrast the personage amalgamation of contact selection and pulse-width (amplitude) to the stimulus parameters that resulted from standard coding derived from quantifiable feature manifestations that are clinical-symptoms. There is no statistical significancy amid AAS scale and standard coding in connection with the precise contact of the electrode pulse-width amplitude employed or in connection with the prognostic and/or diagnostic clinical infection and syndrome sternness. Based on the research results according to the data/ information attained in this study imply that analogue-scale and standard coding techniques lead to parity results interim and instantly. Results also indicate that the examining the Parkinson`s subjective rating as an added or supplementary and legitimate pointer signal for fine-tuning of the personalized stimulus regulation.

 Keywords: Adaptive Closed Loop (ACL), Aesthetic Analogue Scale (AAS), Deep Brain Stimulation (DBS), Microelectrode, Minkowski Distance (MD), Parkinson’s Disease (PD), Subthalamic Nucleus (STN)

Doi No:-10.18231