IP International Journal of Comprehensive and Advanced Pharmacology

Anti-Anemic activity of Hydro-alcoholic extract of Calotropis procera flower on phenylhydrazine- induced anaemic rats

Full Text PDF

Article Type : Original Article

Author Details: Kushwaha Hariom, Ankur Joshi, Sapna Malviya, Anil Kharia

Volume : 2

Issue : 1

Online ISSN : 2456-9542

Print ISSN : 2581-5555

Article First Page : 6

Article End Page : 10

Abstract

The present study was to evaluate the anti-anaemic activity of Calotropis procera flower of Apocynaceae family. Anemia was induced in rats by intra-peritoneal administration of phenylhydrazine at the dose of 40 mg / kg / day for two days. Hydroalcoholic extract was given orally to anaemic rats at 100 mg/kg and 200 mg / kg body weight, once a day for 28 days. Blood samples were collected from the rats by tail incision on days D0, D2, to the 1^st, 2^nd, 3^rd and 4^th week of treatment and subjected to the analysis of red blood cells (RBC), hemoglobin (Hb) and hematocrit (PCV). Extracts at dose of 100mg/kg and as well 200 mg / kg increased (p <0.001) significantly the number of red blood cells in the 4^th week of treatment when compared with that untreated anaemic group. In addition, the hemoglobin level increased (p<0.01) significantly in the first week of treatment to the rats of groups III and IV which received respectively reference antianaemic (Vitamin B12). The anti-anemic effect of Hydroalcholic aqueous extract was comparable to that of the drug Vitamin B12.

Keywords: Calotropis procera, Anaemia, Hydroalcoholic, Hematological Parameters

Doi No:-10.18231