IP Journal of Urology, Nephrology and Hepatology Science

---

Skin and Nail hyperpigmentation (Melanonychia) due to Cyclophosphamide in case of steroid dependant nephrotic syndrome (SDNS): A rare association

Full Text PDF Share on Facebook Share on Twitter

---

Case Report

Author Details : Lakshminarayana GR*, Sahiba E Ummer, Raghunath KV, Muthukumar R

Volume : 3, Issue : 4, Year : 2020

Article Page : 85-87

Suggest article by email

---

Abstract

Cyclophosphamide (CYC) is one the most commonly used second line drug in treatment of nephrotic syndrome, especially in those who are steroid dependant or with frequent relapses. Use of CYC may rarely cause skin or nail hyperpigmentation (melanonychia) apart from other adverse effects related to immunosuppression or cytopenias or hemorrhagic cystitis. We present a patient of steroid dependent nephrotic syndrome (SDNS) who developed blackish brown discoloration of nails and periungual skin folds.

Keywords:  Nephrotic syndrome, Cyclophosphamide, Melanonychia, Hyperpigmentation, Black chromonychia.

How to cite : Lakshminarayana Gr, Ummer S E, Raghunath Kv, Muthukumar R, Skin and Nail hyperpigmentation (Melanonychia) due to Cyclophosphamide in case of steroid dependant nephrotic syndrome (SDNS): A rare association. J Urol Nephrol Hepatol Sci 2020;3(4):85-87

Copyright © 2020 by author(s) and J Urol Nephrol Hepatol Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)