IP Journal of Urology, Nephrology and Hepatology Science

Nephrotoxicity, its mechanism and biomarkers: A systematic review

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Article Type : Review Article

Author Details: Hemalatha S*,Shivakumar Swamy,Narayan Sha Sonar,Hariprasad M.G,Nandini S

Volume : 2

Issue : 4

Online ISSN : XXXX

Print ISSN : XXXX

Article First Page : 45

Article End Page : 49

Abstract

Nephrotoxicity is a common condition responsible for variety of pathologic conditions on kidney due to the destruction of renal function by one or more nephrotic substance. For renal injury to occur, combination of risk factors (drug, kidney and patient related factors) are generally present. The mechanism involved in nephrotoxicity include altered intraglomerular haemodynamic, crystal nephropathy, inflammation, tubular cell necrosis, throbotic microangiopathy, rabdomyolysis. Nephrotoxicity can be assessed by estimating the blood urea nitrogen (BUN), centralization of serum creatinine, glomerular filtration rate and creatinine clearance. Development of new biomarkers are required for specific diagnosis of nephrotoxicity at earlier stages.

Keywords: Nephrotoxicity, Risk factors, Mechanism, Biomarkers.

Doi No:-10.18231