IP Journal of Urology, Nephrology and Hepatology Science

Acute graft dysfunction secondary to rhabdomyolysis following intra-operative lower limb ischemia in a renal transplant recipient

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Article Type : Case Report

Author Details: Umapati Hegde*,Amitkumar Jojera,Shailesh Soni,Mohan Rajapurkar

Volume : 3

Issue : 1

Online ISSN : XXXX

Print ISSN : XXXX

Article First Page : 20

Article End Page : 22

Abstract

We present a case of second renal transplant recipient, who developed myoglobinuric   Acute Kidney Injury (AKI). He was given Basiliximab induction with Cyclosporine, Mycophenolate and steroid as immunosuppression. The blood supply to both the lower limb was from left external iliac artery due to due to ligation of  right external iliac artery fungal aneurysm following nephrectomy of the previous graft in  in right iliac fossa. During present transplant vascular anastomosis left external iliac artery was clamped. He developed both lower limb pain in post-operative period. Graft biopsy showed acute tubular necrosis and no evidence of rejection or clacineurin toxicity. His urine and serum myoglobulins were raised. Immuno-histochemical (IHC) staining of the biopsy with anti- myoglobin antibody showed presence of myoglobin in the tubular cells. 

Keywords: Acute kidney Injury, Rhabdomyolysis, Renal transplant, Muscle ischemia.

Doi No:-10.18231