IP Journal of Urology, Nephrology and Hepatology Science

Management of COVID-19 using metformin: Repositioning against SARS-Cov-2

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Article Type : Review Article

Author Details: Rajesh Kumar,Nita Bharti,Saurabh Kumar,Gian Prakash*,Gaurav Bhasker

Volume : 3

Issue : 3

Online ISSN : XXXX

Print ISSN : XXXX

Article First Page : 52

Article End Page : 58

Abstract

Metformin is an inexpensive, widely available, safe and well-tolerated drug used for the management of type 2 diabetes mellitus. Its broad spectrum of activities has encouraged researchers to allude its efficacy in treating COVID-19 infection in affected population. Its immunomodulatory effect, ability to reduce tumor necrosis factor-?, increase interleukin-6 and activation of AMP activated protein kinase are key aspects in protection against COVID-19 infection. Studies demonstrate that metformin may help treat deadly virus in the absence of a specific treatment or vaccine. It lowered the death rate of elderly patients with COVID-19, diabetes and obesity through decrease of weight and pneumonia. It has regenerative effect in lung fibrosis, thus benefiting the patients in acute, chronic as well as recovery phases of COVID-19 infection. However, more prospective studies are warranted to explore its precise mechanism and efficacy in diverse population. The current review provides an overview of cost-effective metformin’s role in treatment or prophylaxis of COVID-19 due to its anti-viral property.

Keywords: Inexpensive, Interleukin-6, Pneumonia, Tumor necrosis factor-?, Virus.

Doi No:-10.18231