IP Journal of Urology, Nephrology and Hepatology Science

An analogical study on antihypertensive effect of moxonidine versus clonidine in patients with renal failure

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Article Type : Original Article

Author Details: S. Balakrishnan*

Volume : 4

Issue : 3

Online ISSN : XXXX

Print ISSN : XXXX

Article First Page : 75

Article End Page : 78

Abstract

Background: Hypertension is both a cause and effect of CKD and contributes to its progression. When both exist together the risks of CVD morbidity and mortality are substantially increased. Despite treatment with non-pharmacological interventions and multiple antihypertensive agents, the majority of CKD patients fail to reach target BP.
Objectives: To compare and estimate the antihypertensive effect of Moxonidine versus Clonidine in renal failure patients and to estimate the Quality of life in Renal failure patients
Materials and Methods: A prospective 6 months observational follow up study was done involving 120 patients in renal failure patients suffering from stage 1-5 in the Department of Nephrology, Pushpagiri Medical College Hospital, Thiruvalla, Kerala, India. Patients data collection form was used for recording demographic details of the patients. It was a 6 month study in which blood pressure was recorded before and after treatment with drugs and after 3months of follow up. Quality of life score was obtained using KDQOL- SF 36 questionnaires and Standard WHO questionnaires were used to monitor the adverse effect. Finally analyzed the results.
Results: In this study population majority of patients comes under age of 60-80 years age group, about 30% comes under age group 40-60, 6.5%comes under the age group >80 and 7.5 % comes under <40> Conclusion: This study confirms that the drug Moxonidine showed better result in reduction of blood pressure and improved the quality of life in patients who were on therapy with Moxonidine when compared to Clonidine.

Keywords: Moxonidine, CKD, ADR

Doi No:-10.18231