Panacea Journal of Medical Sciences

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Recent advancements in ropinirole hydrochloride embedded nano-techniques in Parkinson’s treatment

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Original Article

Author Details : Manoj Kumar Katual*, Gurfateh Singh, S L. Harikumar

Volume : 9, Issue : 3, Year : 2019

Article Page : 92-103

https://10.18231/j.pjms.2019.023

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Abstract

Parkinson's Disease (PD) is effecting 7-10 million people of worldwide as the report of WHO 2014. It has proved to be 2^nd most a neuro-degenerative disorder of the central nervous system (CNS). It occurs due to the death of dopamine-generating cells in the substantia-nigra, a region of the midbrain. It is characterized by tremor, rigidity, bradykinesia, dementia, depression and falls or emerges with the progression of the disease. Ropinirole HCl is a low molecular weight, highly water soluble drug. It is rapidly absorbed from the G.I.T and mean peak plasma concentrations have been achieved within 1.5 h after oral doses. The oral bioavailability of Ropinirole HCl is 50% due to extensive first pass metabolism by the liver. Its mean plasma half-life is 5–6 h. The present study tries to enlighten the prior art related to Parkinson's treatment and to prepare Ropinirole HCl loaded Nano-structured lipid carriers (NLC) that may overcome the problem of bioavailability and bypass the blood brain barrier by preparing the intra-nasal drug delivery targeted to the brain thereby decreasing the dosing frequency and increasing patient compliance.

Keywords: Parkinson's Disease, Bioavailability, NLC, Nano-technology.

How to cite : Katual M K, Singh G, Harikumar S L, Recent advancements in ropinirole hydrochloride embedded nano-techniques in Parkinson’s treatment. Panacea J Med Sci 2019;9(3):92-103

Copyright © 2019 by author(s) and Panacea J Med Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)