Panacea Journal of Medical Sciences

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A study to compare clinical efficacy and safety of two different doses of intranasal midazolam as premedication for paediatric surgery

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Original Article

Author Details : Amandeep Singh, Chashamjot Bawa, Aditya Sharma*, Jyoti Raina, Mehak Dureja

Volume : 10, Issue : 2, Year : 2020

Article Page : 96-103

https://10.18231/j.pjms.2020.023

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Abstract

Introduction: Intranasal midazolam is convenient form of premedication in children with favourable pharmacokinetics and no side-effects. This study was carried out to compare two different doses of intranasal midazolam as premedication in paediatric surgery.
Materials and Methods: After taking institutional ethics committee approval and informed consent, sixty
patients aged 2 to 6 years undergoing elective surgeries were randomised into two groups (n=30 each) to
receive 0.2mgkg¹ (Group A) and 0.3 mgkg¹ (Group B) intranasal midazolam in the pre-operative area.
Vital parameters were taken at 5 minute intervals till sevoflurane induction. 5-point sedation score was
recorded at 5 minutes, 10 minutes, after parental separation at 15 minutes and modified to show compliance
with fack mask induction at 20 minutes. Side effects during the study were also compiled.
Results: Demographic data including age, gender and weight distribution were comparable in both groups.
All haemodynamic parameters remained similar in both the groups (P>0.05). Significantly higher number
of patients (24 versus 12 in group B and A respectively) had onset of sedation (score 3, 4) at 5 minutes while
sedation levels were comparable at 10 minutes. Lesser number became agitated on parental separation and
face mask induction (P-values 0.044, 0.126 respectively) in group B, former being significant. No side
effects were observed during the study.
Conclusion: Intranasal midazolam in both the dosages provides satisfactory conditions for parental
separation and face mask induction in children. However, larger dose can be used for earlier onset, with
higher probability of adequate sedation levels, no side effects deterring its use.

Keywords: Premedication, Sevoflurane, Midazolam, Paediatric.

How to cite : Singh A, Bawa C , Sharma A , Raina J , Dureja M , A study to compare clinical efficacy and safety of two different doses of intranasal midazolam as premedication for paediatric surgery. Panacea J Med Sci 2020;10(2):96-103

Copyright © 2020 by author(s) and Panacea J Med Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)