Panacea Journal of Medical Sciences

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A sarcomatoid malignant mesothelioma diagnostic challenge even on immunohistochemistry

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Case Report

Author Details : Vaishali Atmaram Walke, Sonali Shravan Datar*, Mahananda Tukaram Bele, Balwant Dasharath Kowe

Volume : 10, Issue : 2, Year : 2020

Article Page : 167-170

https://10.18231/j.pjms.2020.035

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Abstract

Sarcomatoid mesothelioma a rare variant accounts for 10-15% of malignant mesothelioma having a fatal
outcome. Therefore it becomes essential to differentiate sarcomatoid mesothelioma from other variants.
Morphologically it mimics malignant spindle cell tumor. Immunohistochemistry therefore becomes
mandatory to offer definitive diagnosis. However IHC markers also show overlapping expression, making
its interpretation difficult. In such challenging situations, clinicoradiological features, morphology together
with panel of IHC markers help to solve the riddle/dilemma. Here we report a case of sarcomatoid
mesothelioma with its varied IHC profile posing diagnostic challenge.

Keywords: Sarcomatoid mesothelioma, Immunohistochemistry, Spindle cell tumors.

How to cite : Walke V A , Datar S S , Bele M T , Kowe B D, A sarcomatoid malignant mesothelioma diagnostic challenge even on immunohistochemistry. Panacea J Med Sci 2020;10(2):167-170

Copyright © 2020 by author(s) and Panacea J Med Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)