Panacea Journal of Medical Sciences

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Outcome of intrapleural fibrinolytic therapy with streptokinase in loculated pleural effusion patients- An experience from zonal hospital of Eastern India

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Original Article

Author Details : Rajat Shukla, A K Singh, Sumeet Arora, A R Rajan, Ajai Kumar Tentu*

Volume : 10, Issue : 3, Year : 2020

Article Page : 250-257

https://10.18231/j.pjms.2020.052

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Abstract

Background: Loculated pleural effusion is one of the most common clinical entities which are usually caused by empyema, tubercular pleural effusion, malignancy, and hemothorax. The role of Intra-pleural Fibrinolytic Therapy (IPFT) with various fibrinolytics has been studied, however its clinical, radiological and functional outcomes are not assessed completely.
Objective: This is a pre and post intervention study conducted at tertiary care hospital to assess the role of IPFT with streptokinase in patients with loculated pleural effusion.
Results: 102 patients underwent IPFT with streptokinase. Out of 102 patients, 84 patient were male and 18 were females. Main preprocedure diagnosis were tuberculosis (n=70), pneumonia (n=21) and malignancy (n=11). The patients were subdivided into three groups based on sonologically assessed amount of intrapleural fluid - Group 1 (<100ml>200ml). During pre and post IPFT procedure the number of patients identified in group 1 were 30 and 80, group 2 were 40 and 22, group 3 were 32 and none respectively. The mean residual pleural fluid drained before and after IPFT were 190.80ml and 57.84ml (p value<0> Conclusion: IPFT with streptokinase is a safe option in loculated pleural effusion with no major adverse effects.

Keywords: Intrapleural Fibrinolytic Therapy, Loculated pleural effusion, Fibrinolytics.

How to cite : Shukla R, Singh A K, Arora S, Rajan A R, Tentu A K, Outcome of intrapleural fibrinolytic therapy with streptokinase in loculated pleural effusion patients- An experience from zonal hospital of Eastern India. Panacea J Med Sci 2020;10(3):250-257

Copyright © 2020 by author(s) and Panacea J Med Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)