Panacea Journal of Medical Sciences

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An invitro study of synergetic effect of Vitamin C on antimicrobial activity of antibiotics against isolated from respiratory samples

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Original Article

Author Details : Sowmya Nasimuddin*, Jeevan Malaiyan, Mohanakrishnan Kandasamy, Nithyalakshmi J, Kamalraj M, Sumathi G

Volume : 11, Issue : 2, Year : 2021

Article Page : 177-181

https://10.18231/j.pjms.2021.039

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Abstract

Vitamins are essential for various biological responses such as immune function and gene expression in humans. The infections of respiratory tract with is quite common throughout the world. Vitamin C supplements reduces the duration and symptoms of the respiratory infections shown by few therapeutic trials. This study was undertaken to find out whether Vitamin C has got any effect upon the sensitivity pattern of antibacterial prescribed for isolated from respiratory samples using disc diffusion method in vitro. In our study, by using student T test analysis, Vitamin C significantly decreased the inhibition zone of antibiotics Ciprofloxacin (40%), Imipenem (72%) indicating a decrease in their antibacterial effect invitro. Also, Vitamin C enhanced the antibacterial effect of Doxycycline (64%) and Ceftazidime-Clavulanic acid (36%) significantly. Significant decrease in zone diameter was observed on addition of Vitamin C to antibiotics, Imipenem (56%), Ciprofloxacin (40%). It is to be noted that effect of Vitamin C on Ceftazidime-Clavulanic acid is both increase and decrease in zone diameter which were also statistically significant. This might be due to small sample size of isolates (Number – 50) undertaken in the study. The observations noted in this study need further development in terms of increased number of isolates and proper standardization of Vitamin concentrations, with respect to each antibiotic. Being an invitro study, it does not establish any chemical interactions between Vitamins and antibiotics and needs further research by clinical methods.
Key Messages: The interaction of Vitamin C on antibacterial against common respiratory pathogens needs further exploration in the area of research as they show interesting results when studied invitro under a small sample size.
 

Keywords: Vitamin C, Klebsiella pneumoniae, Antibacterials

How to cite : Nasimuddin S, Malaiyan J, Kandasamy M , Nithyalakshmi J, Kamalraj M, Sumathi G, An invitro study of synergetic effect of Vitamin C on antimicrobial activity of antibiotics against isolated from respiratory samples. Panacea J Med Sci 2021;11(2):177-181

Copyright © 2021 by author(s) and Panacea J Med Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)