Panacea Journal of Medical Sciences

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Comparison of nebulised dexmedetomidine versus nebulised ketamine versus nebulised dexmedetomidine-ketamine as premedication in peadiatric surgery

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Original Article

Author Details : Gadkari Charuta, Jirapure Rushikesh*, Deshmukh Shubhada, Wakode Neha, Bhure Anjali

Volume : 11, Issue : 3, Year : 2021

Article Page : 425-430

https://10.18231/j.pjms.2021.084

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Abstract

Aim and Objectives: The present study was undertaken to compare the efficacy of nebulized dexmedetomidine, nebulized ketamine and combination of nebulised dexmedetomidine and ketamine for premedication in pediatric patients.
Materials and Methods: Total 75 children aged between 3-6 years, ASA grade I and II, posted for elective surgery were enrolled and divided into three equal groups. Group D was premedicated with nebulized dexmedetomidine (2mcg/kg), group K was premedicated with nebulized ketamine (2 mg/kg), and group DK was premedicated with combined nebulized dexmedetomidine and ketamine (1 mcg/kg + 1 mg/kg). Primarily, patients were assessed for level of sedation, parental separation and mask acceptance at induction. Secondary assessments were hemodynamic parameters and immediate side effects if any.
Results : Studied groups were comparable as regards to demographic data and haemodynamic parameters. At all-time intervals except at 20 minutes, mean sedation scores were comparable among the three groups (p>0.05). At 20 minutes, group K had significantly higher sedation scores when compared to group D and group DK. The mean parental separation scores of group D, group DK and group K were 1.65 ± 0.48, 1.62 ± 0.49 and 1.37 ± 0.49 respectively, (p>0.05). The mean mask acceptance score of group D, group DK and group K were 1.73 ± 0.54, 1.73 ± 0.68 and 1.43 ± 0.66 respectively, (p>0.05). None of the patient had any immediate side effects.
Conclusion: Dexmedetomidine (2mcg/kg), Ketamine (2mg/kg) and combination of Dexmedetomidine and Ketamine (1mcg/kg and 1mg/kg) as premedication via nebulisation route in pediatric patients is efficacious and safe. Combination of dexmedetomidine and ketamine did not increase the success of premedication.
 

Keywords: Premedication, Nebulization, Dexmedetomidine, Ketamine, Sedation, Induction

How to cite : Charuta G, Rushikesh J, Shubhada D, Neha W, Anjali B, Comparison of nebulised dexmedetomidine versus nebulised ketamine versus nebulised dexmedetomidine-ketamine as premedication in peadiatric surgery. Panacea J Med Sci 2021;11(3):425-430

Copyright © 2021 by author(s) and Panacea J Med Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)