Panacea Journal of Medical Sciences

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Left ventricular dysfunction in patients with HIV/AIDSon HAART in correlation with CD4 count

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Original Article

Author Details : Teena Thomas, Ranjan Kumar Sen, Jagannath Sarangi, Bibhu Prasad Behera*

Volume : 12, Issue : 1, Year : 2022

Article Page : 45-52

https://10.18231/j.pjms.2022.009

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Abstract

Background: According to World Health Organization (WHO) global HIV report 2019, people living with HIV is about 38 million. Especially after the advent of antiretroviral therapy (ART), in PLHIV, cardiovascular complications signify an increasingly important health concern. This vastly active HAART regimen has provided more efficient prophylactic treatment. With the increased duration of survival, this has progressed to an increased episodes of cardiovascular complications associated with PLHA.
Aim of the study: The following review overviews the left ventricular dysfunction in patients with HIV infection on HAART focusing on early diagnosis, therapy and prognosis.
Materials and Methods: It is a Cross sectional study conducted on HIV infected patients attending ART clinic and admitted in medicine wards of MKCG medical college & Hospital from MARCH 2017 to OCTOBER 2018 were included in the study.
Results: Maximum patients were in the age group 25 – 49 years (68.44%) in our study. Mean age of the study group 41.32 + 11.24 years. Gender distribution shows that 82.46% of the patients were males and 14.04% were females. 4 (7%) patients have cardiac disorder. All the patients having cardiac disorders are male. Only 2 patients (3.5%) had left ventricular dysfunction with reduced ejection fraction.
Conclusions: Males are involved more than females. Most patients are in the middle age group between 25 – 49 years. Heterosexual mode was the most common mode of transmission. Most of the study population belonged to rural area 61.4%. Three patients (5.3%) were on anti tubercular drugs. The systolic LV dysfunction was found in 50% of PLHA patients with cardiac disorders. CD4 count was positively correlated with fractional shortening. Presence of cardiac dysfunction was significantly associated with the adherence to ART treatment.
 

Keywords: HIV­infected, Left ventricular dysfunction, CD4 count, Ejection fraction, Fractional shortening

How to cite : Thomas T, Sen R K, Sarangi J, Behera B P, Left ventricular dysfunction in patients with HIV/AIDSon HAART in correlation with CD4 count. Panacea J Med Sci 2022;12(1):45-52

Copyright © 2022 by author(s) and Panacea J Med Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)