Panacea Journal of Medical Sciences

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Utility of haematological parameters and NESTROFT as screening tools for thalassemia trait- A study in a tertiary care hospital

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Original Article

Author Details : Rima Kamat, Shilpa Gatlewar, Sangeeta Kini*

Volume : 12, Issue : 2, Year : 2022

Article Page : 393-398

https://10.18231/j.pjms.2022.074

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Abstract

Background: Thalassemia being one of the commonest causes of anaemia, screening remains is the backbone for diagnosing traits. Considering expensive confirmatory diagnostic tests, aim of this study was to study utility of haematological parameters and NESTROFT as screening tools for thalassemia trait.
Materials and Methods: It is a one and half year prospective study from June 2017 to December 2018, carried out in outdoor patients investigated in central laboratory of a tertiary care centre. A total of 5000 cases were randomly selected based on low haemoglobin values as per WHO Criteria. All the haematological parameters of the complete hemogram performed, were thoroughly analysed. Mentzer Index (MI) and Ehasani Index (EI) were calculated. NESTROFT was performed in all study samples and results were compared with haematological parameters. Results were compiled and statistically analysed.
Results: Out of total 5000 cases with low haemoglobin, mean haemoglobin was 10.12+1.29. Age ranged between 1-82 years with mean age 36.22+16.50 years with female preponderance. NESTROFT was positive in 152 cases (3.04%) and haematological parameters such as RBC, Hemoglobin, MCV were found to be significant (p<0> Conclusion: This study concludes that both haematological parameters and NESTROFT have to be used in conjunction as the primary screening tool for thalassemia traits in general population. Thus making it an ideal contender to be adopted in rural settings of developing countries, for early diagnosis and decreasing the morbidity associated with thalassemia.
 

Keywords: NESTROFT, Mentzer index, Ehasani index, Thalassemia trait

How to cite : Kamat R, Gatlewar S, Kini S, Utility of haematological parameters and NESTROFT as screening tools for thalassemia trait- A study in a tertiary care hospital. Panacea J Med Sci 2022;12(2):393-398

Copyright © 2022 by author(s) and Panacea J Med Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)