Panacea Journal of Medical Sciences

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Prevalance of serologic weak D in Rh D negative blood donors in India: Immunohematological problems & recommendations for donors

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Original Article

Author Details : Ashutosh Singh, Archana Solanki, Devisha Agarwal, Tulika Chandra*

Volume : 12, Issue : 3, Year : 2022

Article Page : 686-689

https://10.18231/j.pjms.2022.127

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Abstract

Background: The Rhesus (Rh) system is one of the most complex blood group systems in humans. In some individuals Rh D antigen show weaker expression on red cells. The aim of the study was to find out the prevalence of serologic weak D in north India and associated immunohematological problems.
Material and Methods: Cell and serum grouping were performed on all sample with the help of Qwalys 2 & Qwalys 3 (Diagast, France). All Rh D negatives samples in routine blood grouping were subjected to serologic weak D testing with the help of Erythrocytes Magnetized (EM) Technology.
Results: Total 65,407 whole blood donors were tested for blood grouping in the study period. Prevalence of serologic weak D phenotype in this study was 1.11% of Rh negative donors. The maximum number of serologic weak D phenotype were from B blood group, i.e. 13 (37.14%).
Conclusion: The prevalence of serologic weak D varies in different part of India as well as in the world. This study reported 1.11% prevalence of serologic weak D among Rh D negative blood donors. All serologic weak D positive individuals should give a blood group card showing their Rh D status as donor and recipient. Some European centers started routine RHD gene screening of first-time donors to eliminate the risk of Rh D sensitization. Molecular testing is very costly.For developing countries like India we required an affordable molecular testing technique to improve patient care or alternatively establish reference molecular laboratory for cost effectiveness.
 
Keywords: Rhesus system, weak D, Erythrocytes Magnetized Technology, Molecular testing

How to cite : Singh A, Solanki A, Agarwal D, Chandra T, Prevalance of serologic weak D in Rh D negative blood donors in India: Immunohematological problems & recommendations for donors. Panacea J Med Sci 2022;12(3):686-689

Copyright © 2022 by author(s) and Panacea J Med Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)