Panacea Journal of Medical Sciences

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Does vitamin D play a role in uterine fibroids? A case control study

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Original Article

Author Details : Lizann Elizabeth Thomas*, Elizabeth Abraham, Renjitha Bhaskaran

Volume : 13, Issue : 2, Year : 2023

Article Page : 323-327

https://10.18231/j.pjms.2023.062

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Abstract

Introduction: Uterine fibroids are monoclonal tumors of uterine smooth muscle cells. They are found in 20-40% of females in the reproductive age group. Ovarian hormones play an important role in its etiology. Recent studies have shown that low serum 25(OH)vitamin D levels are associated with increased risk of uterine fibroids.
Aim: To investigate the association between serum vitamin D levels and uterine fibroids.
Materials and Methods: A case control study was conducted in a tertiary care hospital among 183 women between the age of 18-50 years with uterine fibroids who attended obstetrics and gynecology department and 183 women of the same age group who had no uterine fibroids attending comprehensive health checkup clinic. Serum 25(OH)vitamin D levels were estimated in both groups by electrochemiluminescence immunoassay.
Results: Statistical analysis was performed using IBM SPSS version 20.0. P value of <0> Conclusion: Serum 25(OH) vitamin D levels were found to be deficient in both groups irrespective of the presence or absence of uterine fibroids. Hence, it can be concluded that the study conducted in 366 women could not find a direct association between low serum 25(OH) vitamin D levels and uterine fibroids.


Keywords: Uterine fibroids, 25(OH) vitamin D, electro chemiluminescent immunoassay, Ovarian hormones, Vitamin D deficiency

How to cite : Thomas L E, Abraham E, Bhaskaran R, Does vitamin D play a role in uterine fibroids? A case control study. Panacea J Med Sci 2023;13(2):323-327

Copyright © 2023 by author(s) and Panacea J Med Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)