Panacea Journal of Medical Sciences

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Study of her2/neu and ki-67 expression in invasive urothelial carcinoma of bladder and their correlation with grade and stage

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Original Article

Author Details : Sohini Parveen Sarwala*, Ranu Sarkar, Moumita Maity

Volume : 13, Issue : 2, Year : 2023

Article Page : 334-340

https://10.18231/j.pjms.2023.064

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Abstract

Background: Urinary bladder cancer is one of the costliest diseases, which requires lifelong surveillance due to its rapid aggressive clinical course. Here, HER2/neu and Ki-67 expression, is studied, as important prognostic marker with therapeutic implications in invasive urothelial bladder carcinoma (IUBC).
Objective: To study expression of HER2/neu and Ki-67 in histologically diagnosed cases of IUBC and their clinicopathological correlation.
Materials and Methods: An observational, cross-sectional, study was performed in Pathology Department, NRS Medical College, Kolkata, from February 2020 to July 2021. Tissue sections, after proper processing, were stained in H&E. A total of 75 IUBC cases were histopathologically diagnosed with grade and stage. HER2/neu and Ki-67 expression by immunohistochemistry was studied in them; which was compared with clinicopathological variables like age, sex, risk factors, histological type, grade, stage, etc. Statistical analysis software EPI INFO (TM) 7.2.2.2 was used, p<0> Results: Among 75 cases of IUBC, 60% were high grade and 72% were of lower (pT1) stage. HER2/neu was positive in 52% cases; significantly associated with males, haematuria, smoking, necrosis, high grade (p<0 p=0.0005).>50 years age group, haematuria, smoking, necrosis, LVI, high grade (p<0> Conclusion: Positive HER2/neu expression and high Ki-67 index is significantly associated with high grade and stage of tumours. So, these patients may be considered for targeted therapy using Trastuzumab in addition to conventional therapy.


Keywords: Invasive urothelial bladder carcinoma, HER2/neu, Ki-67

How to cite : Sarwala S P, Sarkar R, Maity M, Study of her2/neu and ki-67 expression in invasive urothelial carcinoma of bladder and their correlation with grade and stage. Panacea J Med Sci 2023;13(2):334-340

Copyright © 2023 by author(s) and Panacea J Med Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)