Panacea Journal of Medical Sciences

---

E-cadherin expression – Significance in gastric carcinoma

Full Text PDF Share on Facebook Share on Twitter

---

Original Article

Author Details : Prathipaa R, Divya J*

Volume : 13, Issue : 2, Year : 2023

Article Page : 418-422

https://10.18231/j.pjms.2023.079

Suggest article by email

---

Abstract

Introduction: Gastric carcinoma is aggressive cancer with poor prognosis. E-cadherin is 120 kD calcium mediated transmembrane glycoprotein that forms the cell adhesion molecule which maintains the integrity of epithelial cells by keeping it cohesive. E-cadherin down regulation in gastric cancer is of great significance in the dissociation of epithelial cells, alteration of tumor microenvironment, invasion, tumor genesis and metastasis. 
Aims and Objective: To study the E-cadherin expression in gastric carcinoma and to correlate with the existing clinical and pathological parameters.
Materials and Methods: The study included 100 confirmed cases of adenocarcinoma from gastrectomy specimens. Immunostaining was done with E-cadherin mouse monoclonal antibody and expression studied based on the staining pattern and correlated with various clinico-pathological parameters. Data was statistically analysed by chi square test with calculation of p-value.
Results: E-cadherin expression showed aberrant staining in 87% cases.  E-cadherin expression showed significant correlation with histological types, tumor grade, tumor depth of invasion, lymphovascular invasion and lymphnode involvement. The expression E-cadherin in gastric cancer was aberrant in 100 % of diffuse type and poorly differentiated tumors. 96.61% of lymph node positive cases showed aberrant expression. The cases with aberrant expression were comparatively more in T3 (100%) and T4 (93.75%) tumors.
Conclusion: The study highlights the significance of E-cadherin expression in gastric carcinoma that can be utilised as a potent bio marker for aggressiveness, metastasis and prognosis.
 

Keywords: E-cadherin, Adenocarcinoma, Gastric cancer, Immunohistochemistry, Cell adhesion

How to cite : Prathipaa R, Divya J, E-cadherin expression – Significance in gastric carcinoma. Panacea J Med Sci 2023;13(2):418-422

Copyright © 2023 by author(s) and Panacea J Med Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)