Panacea Journal of Medical Sciences

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Outcomes of additional local antibiotic to local analgesic and vasodilator in acute anal fissure - A randomized controlled study

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Original Article

Author Details : Krishna Gopal, Vivek Kumar Roy*, Sukalyan Saha Roy, Mukesh Kumar, Anjili Kumari

Volume : 13, Issue : 2, Year : 2023

Article Page : 532-537

https://10.18231/j.pjms.2023.099

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Abstract

Background: Acute anal fissure is a common and painful condition of ano-rectal region characterized by tear in the anoderm causing pain during defecation. Mainstay of its treatment is pharmacotherapy with lifestyle modification.
Objective: Current study was undertaken to evaluate the role of add-on local antimicrobial in recovery and relief of symptoms of acute anal fissure in comparison to local anesthetic and vasodilator without any antimicrobial.
Materials and Methods: It was a randomized, assessor-blinded, active-controlled clinical study in which data of 68 eligible participants were analyzed. Participants of both group received local lignocaine and nifedipine and the test group (Group B) received metronidazole ointment in addition. Healing was assessed by clinical examination and pain by Numeric Pain Rating Scale. Sample size was calculated based upon result of older pilot study and the proportion of recovery were assessed by Chi-square test.
Results: After 6 weeks of treatment, 61 out of 68 (i.e., 89.7%) patients receiving add-on antimicrobial recovered completely compared to 75% of the comparator group. Reduction of pain and cessation of bleeding were also significantly better in patients receiving additional antibacterial.
Conclusion: Healing and symptom relief in acute anal fissure is better with addition of local antibacterial along with local vasodilator and anesthetic.
 

Keywords: Fissure in Ano, Local anesthetics, Local anti­bacterial agent, Gastrointestinal hemorrhage, Acute anal fissure

How to cite : Gopal K, Roy V K, Roy S S, Kumar M, Kumari A, Outcomes of additional local antibiotic to local analgesic and vasodilator in acute anal fissure - A randomized controlled study. Panacea J Med Sci 2023;13(2):532-537

Copyright © 2023 by author(s) and Panacea J Med Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)