Panacea Journal of Medical Sciences

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Comparison of central corneal thickness and endothelial cell count among diabetic retinopathy and non-diabetic cases

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Original Article

Author Details : Pranati Chaudhury*, Anita Misra, Niranjan Puthal, Sasmita Sahoo, Bichismita Jena, Rajesh Panda

Volume : 13, Issue : 3, Year : 2023

Article Page : 631-634

https://10.18231/j.pjms.2023.116

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Abstract

Objective: Diabetes is associated with alterations in the structure and functions of corneal endothelial cells. Current research has been carried out to compare the central corneal thickness and endothelial cell density in patients with diabetic retinopathy (DR) and non-diabetic (ND) individuals.
Materials and Methods: A Cross Sectional comparative research was carried out in a tertiary eye care hospital, over the period of two years from April 2021 to March 2023. Among 160 study participants, 80 cases with diabetic retinopathy (DR) and 80 non-diabetic (ND) cases as age matched control have been selected. Thorough Ophthalmic assessment was done. We have included only retinopathy cases as they have longer duration of diabetis and poorer metabolic control, for better comparison of the endothelium parameters with non-diabetics. Specular microscopy has been done in all cases for endothelial cell count evaluation and thickness of cornea has been estimated by Pachymeter. Statistical analysis was carried out by students‘t’ test by comparing the variables between two groups.
Results : P-value was not significant for the mean age and sex distribution in the two groups. Mean endothelial cell density was lesser (2512.12±260.23cells/mm2) in DR than in ND group (2699.10±95.68cells/mm2). Mean central corneal thickness was greater (522.65±36.56?m) in DR than in ND group (486.50±18.67?m) (P<0> Conclusions: Among DR patients, endothelial cell density was significantly reduced and central corneal thickness considerably raised when compared with ND. Our results also suggest that poor metabolic control and advanced Diabetic Retinopathy are risk factors for developing keratopathy.

Keywords: Diabetes, Mean central corneal thickness, Co­efficient of variation, Specular microscopy, Hexagonality, Mean endothelial cell density

How to cite : Chaudhury P, Misra A, Puthal N, Sahoo S, Jena B, Panda R, Comparison of central corneal thickness and endothelial cell count among diabetic retinopathy and non-diabetic cases. Panacea J Med Sci 2023;13(3):631-634

Copyright © 2023 by author(s) and Panacea J Med Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)