Panacea Journal of Medical Sciences

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Role of antituberculous therapy in latent tuberculosis with ocular manifestations

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Original Article

Author Details : M Periyanayagi*, Uma Velpandian, Arthi Mohankumar

Volume : 13, Issue : 3, Year : 2023

Article Page : 785-790

https://10.18231/j.pjms.2023.143

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Abstract

Introduction: Tuberculosis is an airborne infectious illness caused by Mycobacterium tuberculosis, and it is the most common cause of morbidity and mortality worldwide. Extra-pulmonary TB, often known as ocular tuberculosis, can occur alone or in conjunction with pulmonary tuberculosis. Tuberculosis of the eye can be caused by an active infection or a type 4 hypersensitivity reaction.
Aim: To investigate the role of antituberculous therapy in the treatment of suspected intraocular tuberculosis.
Materials and Methods: Based on a clinical diagnosis of Ocular tuberculosis, 46 patients were assessed with a chest X-ray, Mx test, and quantiferon gold assay and treated with ATT.
Results: The results showed that out of 46 patients, 29 were females and 17 were males. There were 34 patients with B/L involvement and 12 with U/L involvement. In addition, 76 percent of individuals tested positive for tuberculin on their skin, indicating latent tuberculosis. Quantiferon gold assay was positive in 19.56 percent of patients. On X-ray chest, 17.3% of patients had a healed old tuberculosis lesion. H/O contact with TB family members was reported in 13.04 percent of patients.
Conclusion: All patients who had ATT therapy had a favourable outcome, with inflammation clearance and non-recurrence.
 

Keywords: Tuberculosis, Antituberculous therapy, Mantoux skin test, and Interferon­gamma release assay

How to cite : Periyanayagi M, Velpandian U, Mohankumar A, Role of antituberculous therapy in latent tuberculosis with ocular manifestations. Panacea J Med Sci 2023;13(3):785-790

Copyright © 2023 by author(s) and Panacea J Med Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)