Panacea Journal of Medical Sciences

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Correlation of serum biomarker (LDH, CRP, IL-8) levels in pre-malignant and malignant lesions of head and neck

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Original Article

Author Details : Harsha Singh, S M Faiz*, Mariyam Parveen, Kriti Bhatt, Abhijeet Singh, Samiullah

Volume : 14, Issue : 1, Year : 2024

Article Page : 117-122

https://10.18231/j.pjms.2024.022

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Abstract

Introduction: A precancerous lesion is often defined as morphologically altered tissue during which the occurrence of carcinoma is more likely than its normal counterpart. Head and neck cancers include cancers of the mouth and therefore the larynx, also as some rarer cancers like cancer of the sinuses, salivary glands, nose, and tympanic cavity. Head and neck cancers are often described as consistent with the sort of cell they begin with. A biomarker could be defined and interpreted as biological molecule which is mostly found in body fluids, blood or even tissues that indicates abnormalities of our body. Here we've taken three biomarkers (LDH, CRP, IL-8) to gauge their level rise in pre-malignant and malignant lesions which are present in our head and neck.
Materials and Methods: Patients attending ENT OPD with primary symptoms indicating premalignant and malignant lesions in the region of head and neck had been included for the analytical study. Complete ENT examination followed by biopsy of the suspicious lesion and blood sample collection was done.
Results: A complete of 30 patients were included in each group of premalignant and malignant lesions. No mean serum rise of serum LDH was noted in premalignant and malignant lesions. A mean serum rise of serum CRP was noted in premalignant lesions but was not noted in malignant lesions. However, both premalignant and malignant lesions noted a mean serum rise of IL-8.
Conclusion: From a future perspective serum evaluation of biomarkers can become a replacement diagnostic modality for the early evaluation of premalignant lesions and malignant lesions and for monitoring the prognosis of an equivalent.
 

Keywords: Lactate Dehydrogenase (LDH), C ­ reactive protein (CRP), Interleukin­ 8 (IL­8), Premalignant lesions, Malignant lesions

How to cite : Singh H, Faiz S M, Parveen M, Bhatt K, Singh A, Samiullah, Correlation of serum biomarker (LDH, CRP, IL-8) levels in pre-malignant and malignant lesions of head and neck. Panacea J Med Sci 2024;14(1):117-122

Copyright © 2024 by author(s) and Panacea J Med Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)