Panacea Journal of Medical Sciences

---

A study to see association between vitamin d level and obstructive sleep apnea

Full Text PDF Share on Facebook Share on Twitter

---

Original Article

Author Details : Shadan Sadaf, Huma Firdaus*, Rajendra Kumar Saini, Mohammad Shameem

Volume : 14, Issue : 1, Year : 2024

Article Page : 222-228

https://10.18231/j.pjms.2024.040

Suggest article by email

---

Abstract

Introduction: Obese patients have low levels of serum 25-hydroxy vitamin D due to feedback inhibition of hepatic synthesis of the metabolite by increased circulating 1,25(OH) vitamin D. Obese individuals have more physical activity which limits their exposure to sunlight resulting in lower levels of 25(OH)D. Sleep fragmentation in OSA leads to daytime drowsiness, fatigue and hence decreased outdoor activity contributing to the same. Hence, OSA aggravates obesity and obesity aggravates OSA creating a vicious cycle and together contribute to the depletion of serum vitamin D level.
Materials and Methods: Patients attending the special clinic of sleep were included in the study and were screened using STOP-BANG scoring system for OSA Patients with score of >2 were included in the study and further underwent polysomnography test. Among the study population, cases had an apnea-hypopnea index (AHI) > 5 in polysomnography and controls had AHI <5> Results: Total ninety-three patients were included in the study, out of whom 59 were cases which formed the OSA group, had mean age of 48.02 ±8.435 years, mean body mass index (BMI) 33.73 ±7.48 kg/m2, mean neck circumference 37.8 cm ±5.08 Mean vitamin D level in the case and control was 21.02 ± 7.27 and 24.48 ± 6.92 respectively with a p value < 0 xss=removed> Conclusion: Different mechanisms play a role in OSA patients affecting. This study shows inverse relationship between vitamin D level and AHI (apnea-hypopnea index) which was statistically significant and vitamin D level was higher in controls than cases. Thus it can be said that 25(OH)D levels and OSAS are related, but it is difficult to establish a direct causal association between them.
 

Keywords: Apnea hypopnea index (AHI), Obstructive sleep apnea, Obesity, Polysomnography, Vitamin D

How to cite : Sadaf S, Firdaus H, Saini R K, Shameem M, A study to see association between vitamin d level and obstructive sleep apnea. Panacea J Med Sci 2024;14(1):222-228

Copyright © 2024 by author(s) and Panacea J Med Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)