Panacea Journal of Medical Sciences

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Anaemia profile in hypothyroid patients

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Original Article

Author Details : Shikha Agarwal*, Praveen Sablain, Mirajul Siddiqui, Mural Manohar Shah, Payal Sharma

Volume : 14, Issue : 2, Year : 2024

Article Page : 337-341

https://10.18231/j.pjms.2024.059

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Abstract

Introduction: Thyroid disease is associated with anaemia is a frequent haemoglobin disorder. Hypothyroidism is a clinical syndrome that results from deficiency of the thyroid hormones, thyroxine (T) and triiodothyronine (T).The prevalence of subclinical hypothyroidism is higher, ranging from 4% to 10% of adults, with possibly a higher frequency in older women. Anaemia is a different types e.g. Iron deficiency anaemia, B12 deficiency anaemia, Sickle cell anaemia, Aplastic anaemia, haemolytic anaemias.Thyroid gland has a very important role in hemopoiesis. In thyroid patients blood disorder are frequently seen as it has role in metabolism of RBC and other blood components. Anaemia can occur when there is not enough oxygen to carry by RBC.
Materials and Methods: This is a case control study which will be conducted in Rama medical college, hospital and department of Biochemistry in Hapur city (U.P). About 100 subjects will be enrolled in the current study including 50 patients with hypothyroidism and 50 with Healthy individual (controls) blood counts as control group. 2ml of EDTA anti coagulated blood and 3ml of whole blood will be taken from these subjects under fully aseptic condition (for CBC,TFT) respectively. EDTA Will be put on mixer instrument for mixing for 5min. CBC will be performed by coulter counter. The haematological parameters which will be studied include Hb, RBC, MCV, PCV. Iron profile (Iron, TIBC, Ferritin) level will be done by EM-200. The other 3ml of whole blood will be put in gel tube, serum will be prepared after centrifugation for 10 min, Thyroid function test including (T3, T4,TSH) based on ELISA.
Results: In this study, we found that T4 and TSH had significant statistical difference (<0> Conclusion : In both people with hypothyroid and participants with hyperthyroid function, we found greater risks of anemia. Additionally, a decreased thyroid function at baseline indicated a tendency toward an elevated risk of anemia throughout follow-up. A randomized controlled research will be necessary to determine whether treating (subclinical) hypothyroidism reduces anemia.
 
Keywords: Anaemia, Hyperthyroid patients, Thyroxine, Triiodothyronine

How to cite : Agarwal S, Sablain P, Siddiqui M, Shah M M, Sharma P, Anaemia profile in hypothyroid patients. Panacea J Med Sci 2024;14(2):337-341

Copyright © 2024 by author(s) and Panacea J Med Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)