Panacea Journal of Medical Sciences

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Evaluation of ovarian parameters before and after clomiphene citrate in eastern Indian women with primary infertility

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Original Article

Author Details : Susmita Ghosh, Oyndrila Sengupta, Srijit Narayan Chaudhuri, Subhajit Halder*, Arunabha Tapadar

Volume : 14, Issue : 2, Year : 2024

Article Page : 371-376

https://10.18231/j.pjms.2024.066

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Abstract

Background: Women’s biologic clocks do not synchronize with our relatively new societal clocks. Advancing female age is one of the “greatest enemies” of fertility. A reduction in hormones from the ovaries with age is therefore thought to decrease the chances for pregnancy. The Clomiphene Citrate Challenge Test (CCCT) is often used to predict the likelihood that a woman can achieve pregnancy using her own eggs.
Aims: To measure the changes of morphometric parameters of ovarian follicles and their numbers and compare the same before and after administration of Clomiphene citrate and also with aging.
Materials and Methods: This interventional cohort study, performed on the women coming to the infertility clinic at Institute of Post Graduate Medical Education& Research, Kolkata with primary infertility of varying age groups. A total of 50 subjects were taken out for the study with their informed consent. Measurements of various parameters of the ovaries were done with Transvaginal ultrasonography. Comparison among them with respect to age, number, volume, length, breadth both before and after ovulation induction with Clomiphene citrate were made.
Result: Statistically significant decline in number of follicle and ovarian volume was seen after 30 years of age on both sides indiscriminately. The volume and length of ovaries and the follicle number are significantly increased following Clomiphene administration. Though the breadth is not significantly changed.
Conclusion: The study confirms that transvaginal ultrasound can provide a reliable measure in monitoring the follicular growth and ovulation. It also proves that clomiphene is one of the best first line drug for induction of ovulation.
 

Keywords: Clomiphene citrate, Ovulation, Ovarian follicle, Ovulation induction, Primary infertility

How to cite : Ghosh S, Sengupta O, Chaudhuri S N, Halder S, Tapadar A, Evaluation of ovarian parameters before and after clomiphene citrate in eastern Indian women with primary infertility. Panacea J Med Sci 2024;14(2):371-376

Copyright © 2024 by author(s) and Panacea J Med Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)