Panacea Journal of Medical Sciences

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Evaluation of MIC Colistin in Metallo-beta-lactamase producing Gram negative bacilli by Broth microdilution

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Original Article

Author Details : Mahalle Rashmi, Hassani Umesh*, Nagdeo Neena

Volume : 14, Issue : 2, Year : 2024

Article Page : 405-408

https://10.18231/j.pjms.2024.072

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Abstract

Introduction: Carbapenemase producing Enterobacterales and nonfermenter organisms like aeruginosa and sp. cause difficult to treat life treating infections. Colistin plays important role in treating such infection. Broth microdilution is recommended by EUCAST and CLSI for MIC determination of colistin.
Materials and Methods: Gram negative bacilli resistant to Imipenem were subjected to test for Metallo-beta-lactamase (MBL) production by Disc potentiation test. MIC determination of colistin was done by Broth microdilution (BMD) in MBL producing isolates.
Result: 20.5% of isolates of , sp., and sp. were found to be MBL producers. All were sensitive to colistin. 1 isolate of sp. and sp. each were found to be resistant. 3 isolates of Acinetobacter sp. were resistant to colistin.
Conclusion: MBL producing Enterobacterales and nonfermentors like sp. showed good sensitivity to colistin. sp. showed 17.64% resistance to colistin.
 
Keywords: Metallo­beta­lactamase, MIC, Colistin, Broth microdilution

How to cite : Rashmi M, Umesh H, Neena N, Evaluation of MIC Colistin in Metallo-beta-lactamase producing Gram negative bacilli by Broth microdilution. Panacea J Med Sci 2024;14(2):405-408

Copyright © 2024 by author(s) and Panacea J Med Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)