Panacea Journal of Medical Sciences

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Antiparkinson’s drug-effects on quality of life and safety among parkinson disease patients- A prospective observational study in a tertiary care hospital of West-Bengal

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Original Article

Author Details : Satyabrata Sahoo*, Asutosh Pal, Syed Mohammad Naser, Chiranjib Bagchi, Santanu Munshi, Mrinal Acharya, Shreyashi Dasgupta, Santanu Kumar Tripathi, Sumalya Sen, Shambo Samrat Samajdar, Sougata Sarkar, Subhashree Sahoo

Volume : 14, Issue : 2, Year : 2024

Article Page : 409-414

https://10.18231/j.pjms.2024.073

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Abstract

Introduction: Parkinson’s disease (PD) is the second most frequent neurodegenerative disease, affecting 1% of the population aged>60 years due to striatal dopamine deficiency. Dopamine replacement with oral levodopa is the gold standard of symptomatic therapy. Longterm therapy with dopamine agonists might lead to decreased benefit and referred to as ‘end of dose deterioration’ or ‘wearing-off. This leads to decrease quality of life of such patients. There might be safety issues due to longterm use of these drugs. There are few studies conducted in India regarding quality of life studies and safety of antiparkinsonian drugs in Parkinson disease patients and none in West-Bengal. Hence this study is taken up in our tertiary care Hospital.
Aims: To study antiparkinson’s drug-effects on quality of life of parkinson disease patients and their safety and tolerability.
Materials and Methods: This prospective, observational study was conducted in Dept of Clinical & Experimental Pharmacology of School of Tropical Medicine Kolkata in collaboration with Departments of Neuromedicine of Kolkata Medical College and Private Clinics of a Neurologist. All Idiopathic Parkinson disease patients from December 2019 to November 2021, were included according to inclusion and exclusion criteria. The study commenced after obtaining approval from institutional ethics committee, and completed in 24 months. Data collected and then statistically analyzed by using WPS Excel and Graph Pad Prism 9 software.
Results: Total Idiopathic Parkinson disease patient were 111 in our study. Anti parkinson drugs were very well tolerated and ADRs were mild in intensity. Antiparkinsonian drugs improve the quality of life significantly.
Conclusion: Antiparkinsonian drugs were well tolerated and safe. Quality of life improved by use of antiparkinsonian drugs in parkinson disease patients.

Keywords: Comorbidity, Wearing-off, life quality, Parkinson disease, safety

How to cite : Sahoo S, Pal A, Naser S M, Bagchi C, Munshi S, Acharya M, Dasgupta S, Tripathi S K, Sen S, Samajdar S S, Sarkar S, Sahoo S, Antiparkinson’s drug-effects on quality of life and safety among parkinson disease patients- A prospective observational study in a tertiary care hospital of West-Bengal. Panacea J Med Sci 2024;14(2):409-414

Copyright © 2024 by author(s) and Panacea J Med Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)