Panacea Journal of Medical Sciences

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Prevalence of hypogonadism in type 2 diabetes mellitus associated with or without obesity: An observational study

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Original Article

Author Details : Suvendu Jana, Snehasis Ghosh, Anjan Debnath, Arup Ghosh*, Partha Sarathi Karmakar, Purba Haldar

Volume : 14, Issue : 2, Year : 2024

Article Page : 466-470

https://10.18231/j.pjms.2024.084

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Abstract

Background: Hypogonadism is associated with type 2 Diabetes Mellitus & obesity in a substantial/sizeable number of men. But studies on prevalence of hypogonadism, major cause of low testosterone in diabetes and/or obesity are very scanty. Recognition of prevalence of hypogonadism in diabetic & obese population could be a very important determinant for proper management with better outcome & wellbeing.
Aims & Objectives: the study was conducted to determine the prevalence of hypogonadism in adult men with diabetes mellitus with or without obesity & to assess the impact of diabetes & increased Body Mass Index on development of hypogonadism in adult males.
Materials and Methods : For operational purpose blood levels of testosterone & gonadotrophins (FSH & LH) were determined in diabetic & obese individuals & also in age matched controls. Detailed history, clinical examination & biochemical investigation helped to exclude other causes of hypogonadism, while anonymous questionnaire based on “The Saint Louis University Androgen Deficiency in Aging Males (ADAM) Questionnaire” & biochemical examination viz. sex hormone binding globulin (SHBG) & total testosterone in serum were used to detect presence of hypogonadism in the cases & controls.
Result: Prevalence of hypogonadism in diabetic subjects was 24.07%, whereas in age matched control population it was only 5.5%. In our study the subjects who had > 10 years duration of diabetes had increased prevalence of hypogonadism (66.6%). The study also revealed that increased age is associated with increased prevalence of hypogonadism. Subjects who were > 50 years old were associated with increased prevalence of hypogonadism (36.6%). It was also observed that obese or overweight person had increased prevalence of hypogonadism.
Conclusion: Prevalence of hypogonadism is significantly more in diabetic subjects & increased duration of diabetes is associated with increased prevalence of hypogonadism. It was also found that in addition to diabetes, persons who were obese or overweight had increased prevalence of hypogonadism.
 

Keywords: Hypogonadism, Type 2 diabetes mellitus, Obesity, Adult male

How to cite : Jana S, Ghosh S, Debnath A, Ghosh A, Karmakar P S, Haldar P, Prevalence of hypogonadism in type 2 diabetes mellitus associated with or without obesity: An observational study. Panacea J Med Sci 2024;14(2):466-470

Copyright © 2024 by author(s) and Panacea J Med Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)