Panacea Journal of Medical Sciences

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Role of urinary nephrin to predict early onset of nephropathy in patients with type 2 diabetes mellitus

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Original Article

Author Details : Gadigeppa H Chittaragi*, Anand P Ambali, Rajesh Honnutagi, Veluri Ganesh

Volume : 14, Issue : 2, Year : 2024

Article Page : 497-501

https://10.18231/j.pjms.2024.090

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Abstract

Background: Nephropathy is most common complication in type 2 diabeticsubjects. Urinary nephrin is a podocyte specific protein, can be serve as a predict early nephropathy and its progression of diabetic nephropathy.
Materials and Methods: A total 90 participants included were sub grouped as 60 cases and 30 healthy controls, a biochemical, clinical and experimental parameters were analyzed for all the study subjects. The data was interpreted by using statistics software SPSS and <0> Results: There were significantly increased levels of FBS, PPBS and glycated haemoglobin in type 2 diabetic cases when compared to controls. The urea, creatinine, uric acid and microalbumin were significantly elevated in type 2 diabetic with microalbuminuria when compared to type 2 diabetic with normoalbuminuria and controls. Additionally the urinary nephrin was significantly elevated in both groups of type 2 diabetics when compared to controls.
Conclusion: This study suggests determination of urinary nephrin can be used as an early predictable and prognostic marker for nephropathy in patients with type 2 diabetics.
 
Keywords: Type 2 Diabetes Mellitus, Nephropathy, Nephrin and Microalbumin

How to cite : Chittaragi G H, Ambali A P, Honnutagi R, Ganesh V, Role of urinary nephrin to predict early onset of nephropathy in patients with type 2 diabetes mellitus. Panacea J Med Sci 2024;14(2):497-501

Copyright © 2024 by author(s) and Panacea J Med Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)