Panacea Journal of Medical Sciences

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Evaluation of leptin and lipid profile parameters in patients of T2DM in a tertiary care center of the Kumaun region of Uttarakhand

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Original Article

Author Details : Seema Gupta*, V Satyawali, Sanjeev Shukla

Volume : 14, Issue : 3, Year : 2024

Article Page : 617-623

https://10.18231/j.pjms.2024.110

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Abstract

Introduction: In India, T2DM is a major health problem due to its rising prevalence and associated complications. The role and mechanism of leptin and insulin in the etiopathogenesis of type 2 diabetes mellitus have been studied and reviewed in varying ethnic populations. However in the Kumaun region of Uttarakhand studies regarding the association of leptin and insulin in type 2 diabetes are lacking, for this the present study was conducted.
Materials and Methods:  A total of 100 subjects, including fifty known T2DM patients and fifty healthy Age, Gender [Manish1] and BMI matched controls were[Manish2] enrolled in this cross-sectional study. Anthropometric and biochemical parameters including leptin, insulin, fasting glucose, HbA1c, and lipid profile were estimated in all the subjects by standard protocols.
Results: Higher leptin levels (p< 0 r=0.346, r=0,482,> Conclusions: High leptin levels are associated with insulin resistance and dyslipidemia in diabetic cases in this region.
 

Keywords: T2DM (type 2 diabetes mellitus), Leptin, Homeostatic model assessment-insulin resistance (HOMA IR)

How to cite : Gupta S, Satyawali V, Shukla S, Evaluation of leptin and lipid profile parameters in patients of T2DM in a tertiary care center of the Kumaun region of Uttarakhand. Panacea J Med Sci 2024;14(3):617-623

Copyright © 2024 by author(s) and Panacea J Med Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)