Panacea Journal of Medical Sciences

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Expression of CD44 and Ki-67 in oral squamous cell carcinoma

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Original Article

Author Details : Harmanpreet Kaur*, Anupam Varshney, Alok Mohan, Varsha Raina, Kunika Singh

Volume : 14, Issue : 3, Year : 2024

Article Page : 871-876

https://10.18231/j.pjms.2024.155

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Abstract

Objectives: The present study was done to evaluate the immunohistochemical expression of CD44 and Ki-67 in cases of oral squamous cell carcinoma.
Materials and Methods: A Hospital based observational study was conducted at the Department of pathology, in a tertiary teaching hospital in western Uttar Pradesh. The study included specimens of oral lesions undergone incisional biopsies and/or radical complete surgical resection diagnosed as squamous cell carcinoma. Specimens were grossed, processed, paraffin embedded, appropriate sections were taken and Haematoxylin and eosin stained, then examined under microscope. Immunohistochemical markers- CD44 and Ki-67 were applied.
Results: Most common sites were tongue (40.0%) and buccal mucosa (35.0%). The correlation of CD44 and Ki-67 score with histological grades in Oral Squamous Cell Carcinoma were significant in all three grades i.e., grade1, grade 2 and grade 3.
Conclusion: The immunoexpression of CD44 may have prognostic significance in determining the tumour’s stage, grade, degree of invasiveness, and likelihood of metastasis. Ki-67 is a simple to use indicator of cell proliferation whose expression is positively correlated with the development of illness. As a result, it is a marker of carcinogenesis and malignant transformation in oral premalignant lesions. IHC methods may be costly and time-consuming, but their evaluation could be utilised to guide treatment choices for individuals with OSCC.
 

Keywords: Immunohistochemistry, Oral cavity, Squamous cell carcinoma, CD44, Ki­67

How to cite : Kaur H, Varshney A, Mohan A, Raina V, Singh K, Expression of CD44 and Ki-67 in oral squamous cell carcinoma. Panacea J Med Sci 2024;14(3):871-876

Copyright © 2024 by author(s) and Panacea J Med Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)