Panacea Journal of Medical Sciences

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Methemoglobinemia with hemolytic anaemia as a result of acute dapsone intoxication

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Case Report

Author Details : Ambuj Yadav, Deepak Bhagchandani, Mahak Lamba*, Himanshu Dandu, Pahul Ahuja

Volume : 14, Issue : 3, Year : 2024

Article Page : 889-891

https://10.18231/j.pjms.2024.158

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Abstract

We describe a case of methemoglobinemia byacute dapsone intoxication in a 24-year-old female who ingested 20 tablets of Dapsone 100mg. The patient was admitted to the Medicine Emergency and Trauma Centre (METC) at King George's Medical University, Lucknow. On presentation, she exhibited respiratory distress, restlessness, altered behavior, and cyanosis of the lips and fingertips. Arterial blood gas analysis revealed dark brown colored blood with abnormal parameters, including a pH of 7.481, methemoglobin level of 26.6%, and a low oxygen saturation level. Gastric lavage was performed in the casualty department, and the patient was subsequently transferred to the Intensive Care Unit. Treatment involved administration of Methylene Blue and supportive care with supplemental oxygen and ascorbic acid and Vitamin E supplementation. The patient's methemoglobin levels gradually decreased, indicating a response to treatment. Laboratory investigations also revealed evidence of concurrent haemolytic anemia. Patient demonstrated improved respiratory distress and behavior by the treatment.
 

Keywords: Dapsone, Methemoglobinemia, Haemolytic Anemia, Cyanosis, Methylene Blue, Intensive Care Unit

How to cite : Yadav A, Bhagchandani D, Lamba M, Dandu H, Ahuja P, Methemoglobinemia with hemolytic anaemia as a result of acute dapsone intoxication. Panacea J Med Sci 2024;14(3):889-891

Copyright © 2024 by author(s) and Panacea J Med Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)