Introduction
Drug induced thrombocytopenia is clinical disorder, caused due to administration of therapeutic drugs for management of various diseases.1 More than 300 drugs are identified that can cause drug induced thrombocytopenia,1 the symptoms may begin in 5 to 10 days of drug administration, even with single dose administration can cause immediate effects, 2 the stopping of drugs for 1 to 2 days can recover the patients from complication related to drug effects, the common drugs that lead to drug induced thrombocytopenia are quinidine, 3 vancomycin oxaliiplatin, 4 suramin,5 abciximab, tirofiban, 6 heparin.pencillin, 7 sulfonamide, statins, ranitidine, NSAIDs’. Hence the present study designed to study the prevalence of drug induced thrombocytopenia at various selected cities in North India.
Objectives
The present study is aimed to assess the prevalence of drug induced thrombocytopenia in multiple cities at north India.
Materials and Methods
A survey study designed to assess the prevalence of drug induced thrombocytopenia in multiple cities at north India in Lakhimpur, Panipat, Sonipat, Gohana, Delhi for a period of 11 months from January 2022 to November 2022. A total of 5440 samples from 5 cities were selected from different diagnostic centers, of these at Lakhimpur 1050 samples, Panipat 1465 samples, Sonipat 815 samples, Gohana 845 samples, Delhi 1265 samples respectively were collected with symptoms of decreased platelets count and diseased associated with clinical picture, the blood samples were collected for assessing the thrombocytes count.
Table 1
List of drugsused that caused drug induced thrombocytopenia and number of patients used the respective drugs
Results
The present study is designed to assess the prevalence of drug-induced thrombocytopenia. The following are the findings of the study.
Table 2
Describes the distribution of the drug induced thrombocytopenia cases at various cities under study.
Table 2, describes the distribution of drug induced thrombocytopenia cases at various selected cities of North India, in Lakhimpur total 1050 samples were collected of them 39 samples, in Panipat total 1465 samples were collected 66 samples, in Sonipat total 815 samples were collected of them 63 samples, in Gohana total 845 samples were collected of them 40 samples and in Delhi total 1265 samples were collected of them 53 samples were drug induced thrombocytopenia respectively.
The study also found that prevalence of drug induced thrombocytopenia in total samples of 5440, at Lakhimpur is 3.7%, Panipat is 4.5%, Sonipat is 7.7%, Gohana is 4.7%, Delhi is 4.1% respectively and total prevalence of drug induced thrombocytopenia in North India is 4.7% is represented in pie diagram.
Table 3
Describes the distribution of gender of the samples having drug induced thrombocytopenia.
FromTable 3, the study found that out of 261 total drug induced thrombocytopenia cases 165 (63.21%) were males and 96 (58.18%) were females. Among which in Lakhimpur out of 39 samples 20 (12.12%) were males and 19 (19.79%) were females, at Panipat in 66 samples 40 (24.24%) were males and 26 (27.08%) were females, at Sonipat 63 samples collected of which 43 (26.06%) were males and 20 (20.83%) were females, at Gohana total 40 samples of them 18 (10.90%) were males and 22 (22.91%) were females and at Delhi 53 samples of them 44 (26.66%) were males and 9 (9.37%) were females respectively, signifies that the prevalence of drug induced thrombocytopenia was high in male than in females.
Table 4
Describes the distribution of the samples according to their age in years.
Table 4, describes the distribution of the samples as per their age in years, in Lakhimpur out of 39 drug induced thrombocytopenia samples 20 to 40 years aged samples were 15(38.46%), 41 to 60 years aged were 15(38.46%) and more than 61 years were 9(23.07%), in Panipat out of 66 drug induced thrombocytopenia samples 20 to 40 years aged samples were 23(34.84%), 41 to 60 years aged were 24 (36.36%) and more than 61 years were 19 (28.78%), in Sonipat out of 63 drug induced thrombocytopenia samples 20 to 40 years aged samples were 23(36.50%), 41 to 60 years aged were 25(39.68%) and more than 61 years were 15 (23.80%), in Gohana out of 40 drug induced thrombocytopenia samples 20 to 40 years aged samples were 10(25.00%), 41 to 60 years aged were 15(37.50%) and more than 61 years were 15(37.50%), in Delhi out of 53 drug induced thrombocytopenia samples 20 to 40 years aged samples were 25(47.16%), 41 to 60 years aged were 20(37.73%) and more than 61 years were 8(15.09%) signifies that the drug induced thrombocytopenia can cause to any age group.
Discussion
The present study aimed to study the prevalence of the drug induced thrombocytopenia cases in selected various cities at North India. The study was conducted at 5 cities are Lakhimpur, Panipat Sonipat, Gohana and Delhi for a period of 11 month from January 2022 to Noveber 2022 collected 5440 samples of which 261 samples were showed drug induced thrombocytopenia.
The present study designed to distribution of the prevalence of the drug induced thrombocytopenia found that the prevalence is 4.7% in selected cities, these findings were similar to the study. 8, 9, 10, 11
the study witnessed that out of 261 samples 165 (63.21%) were males and 96 (58.18%) were females these finding were similar to study 12, 13, 14, 15, 16 and the study also found that the age of drug induced thrombocytopenia is similar in all age groups these findings were similar to the study. 17, 18
Conclusion
Cytotoxic drugs when administered for therapeutic purpose caused drug induced thrombocytopenia, the knowledge of prevalence of disorder prevent the incidence of the disorder and the minimal use of cytotoxic drugs, the present study found that prevalence of drug induced thrombocytopenia as 4.7% which is evident by other studies. This prevalence of drug induced thrombocytopenia in selected cities of North India gives a relevant information to control and prevent the disorder and manage patients as needed.
