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Jujara, Yadav, Jadhav, Dhanusu, Sonawane, and Yadav: Depression among COVID positive and negative cases-An analytical study in Mumbai City, India


Introduction

The Kerala govt announced a lockdown on 23rd march and the rest of the state declared a lockdown on 25th march 2020.1 Following that, the number of cases increased, and a nationwide lockdown was enforced in India. The socio-economic damage has affected people who were poor and had no proper shelter or roof. Metropolitan cities like Mumbai which has a huge migratory population living in the slums and chawls have faced difficulty in daily earnings. Residential mobility increased during the lockdown at the least in Northeastern states while extreme in the Northern state of India. 2 The mental health of people had also been affected due to high death tolls, unemployment, financial crisis, family and socialization, business, and lack of opportunity. Mental health was affected in various dimensions as parent-child interaction and stigma and isolation of COVID-positive family members especially elderly persons with comorbidities.

During COVID-19 Pandemic there were Human Behavior Changes which has caused depression among Humans. 3 About 14% of the global burden of disease has been attributed to neuropsychiatric disorders, mostly due to the chronically disabling nature of depression and other common mental disorders. 4 Mental health during the pandemic has been long neglected even though it causes substantial loss of disability-adjusted life years. India spends <2% of its annual health budget on mental health. 5 Resilience to poor mental health varies across demographics, most notably by age, gender, employment status, financial situation, and socioeconomic status. Young people, those living alone, those with lower socioeconomic status, and those who were unemployed were more likely to be in mental distress. The previous study showed the behavior changes in the Covid-19 pandemic situation towards the local people and their work like close contact mask-wearing has resulted in depression among humans which accounts for 15.97% to 20.86% prevalence. 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21

Objectives

  1. To estimate the prevalence of depression among COVID-19 positive and negative patients

  2. To explicate the relationship between factors causing depression among COVID-19 positive and negative patients in Mumbai.

Materials and Methods

It is a cross-sectional analytical study with a sample size of 156. All COVID-19 RTPCR positive and negative patients of a containment zone during the period of 18 days (12th September 2020 to 1st October 2020). Through consecutive sampling 78 individuals having COVID-19 RTPCR reported Positive were included as cases and 78 detected negative for COVID-19 RTPCR as a comparative group in the ratio of 1:1. The prevalence of depression was studied in both positive and negative cases of COVID-19 by applying the DSM 5 scale (Fifth edition of Diagnostic and Statistical Manual of Mental Disorders used). Cognitive, emotional, behavioural and physiological processes are far more complex than what can be described in forms. The general convention in DSM-5 is to allow multiple diagnoses to be assigned to meet the criteria for more than one DSM-5 disorder. As per the DSM-5 scale questionnaire was formed with responses graded as ‘Not at all=0’, ‘Rare, less than a day or two=1’, ‘More than half a day=2’, ‘several days=3’and ‘nearly every day=4’. The total score of each question was calculated with a scoring scale. A score equal to or less than 8 is concluded as a depressive state. 22 A significant cause for depression in COVID -19 positive and negative cases was further analysed with Logistic Regression. After getting consent, a questionnaire was used as a tool for data collection and responses collected. Due to COVID appropriate precaution was taken while interacting with study subjects.

Results

As per the data analyzed, 42.95% (n=67) of the respondents were females while 57.05% (n=89) were males.Equal set (n=78) of COVID positive and negative respondents were selected under the study. The population under study were analyzed for indicators like social behavior changes noticed by family members, effects of urbanization on mental health, fear of survival, fear if anyone visits home, fear of going outside for basic necessities like groceries, decreased social-interaction and its impact on mental health,any financial crisis arising in the family or increased expenditure due to pandemic situation. The respondents belonged to varied age groups.The lowest aged respondents in both the groups, namely the covid positive and covid negative group were of 19 years while the respondent aged 80 years was highest in covid negative group and 87 years in the covid positive group. The average in covid positive group was 44.79 years while in covid negative group it was 40.37 years. All the major findings of the study are enlisted in depth in form of tables (Table 1, Table 2, Table 3, Table 4) and figures (Figure 1, Figure 2) at the end of the article.

Table 1

Depression status and socio-demographic variables

S.No

Variables (n=156)

Yes/No

Depression status as per DSM5

Total

Mid-p exact

Odds Ratio

95% Confidence Interval

Yes

No

Lower

Upper

1

Gender

Female

42(54.55%)

25(31.65%)

67(42.95%)

0.002*

2.575

1.343

5.004

Male

35(45.45%)

54(68.35%)

89(57.05%)

2

COVID19

Positive

39(50.65%)

39(49.37%)

78(50.00%)

0.437

1.052

0.559

1.98

Negative

38(49.35%)

40(50.63%)

78(50.00%)

3

social behaviour changes noticed by society members

Yes

30(38.96%)

21(26.58%)

51(32.69%)

0.051

1.756

0.891

3.498

No

47(61.04%)

58(73.42%)

105(67.31%)

4

Happy with Urbanization

Yes

50(64.94%)

61(77.22%)

111(71.15%)

0.047*

0.548

0.267

1.109

No

27(35.06%)

18(22.78%)

45(28.85%)

5

Fear of survival is in danger

Yes

24(31.17%)

14(17.72%)

38(24.36%)

0.026*

2.092

0.988

4.539

No

53(68.83%)

65(82.28%)

118(75.64%)

6

Fear of going to vegetable market or grocery store

Yes

27(35.06%)

19(24.05%)

46(29.49%)

0.068

1.699

0.845

3.455

No

50(64.94%)

60(75.95%)

110(70.51%)

7

fear of when someone visits home or you visit someone

Yes

21(27.27%)

12(15.19%)

33(21.15%)

0.034*

2.083

0.945

4.734

No

56(72.73%)

67(84.81%)

123(78.85%)

8

less interacting with people even on the phone or online

Yes

35(45.45%)

27(34.18%)

62(39.74%)

0.077

1.600

0.837

3.078

No

42(54.55%)

52(65.82%)

94(60.26%)

9

Affects you mentally most of the time

Yes

24(31.17%)

16(20.25%)

40(25.64%)

0.062

1.776

0.855

3.751

No

53(68.83%)

63(79.75%)

116(74.36%)

10

The financial crisis arises in family

Yes

33(42.86%)

43(54.43%)

76(48.72%)

0.076

0.629

0.332

1.186

No

44(57.14%)

36(45.57%)

80(51.28%)

11

Pandemic increases expenditure of family

Yes

68(88.31%)

76(96.20%)

144(92.31%)

0.036*

0.300

0.063

1.111

No

9(11.69%)

3(3.80%)

12(7.69%)

12

Type of Family

Extended

15(19.48%)

29(36.71%)

44(28.21%)

P- Value

Chi-square

Joint

16(20.78%)

9(11.39%)

25(16.03%)

0.035*

6.6774

Nuclear

46(59.74%)

41(51.9%)

87(55.77%)

Table 2

Depression status and socio-demographic variables in COVID 19 Positive and Negative Cases

S.No

Variables (n=78)

Yes/No

Depression status as per DSM5

Total

Mid-p exact

Odds Ratio

95% Confidence Interval

COVID 19 Positive

Yes

No

Lower

Upper

1

Gender

Female

19(48.72%)

13(33.33%)

32(41.03%)

0.089

1.884

0.751

4.815

Male

20(51.28%)

26(66.67%)

46(58.97%)

2

Fear of going to vegetable market or grocery store

Yes

13(33.33%)

6(15.38%)

19(24.36%)

0.036*

2.714

0.915

8.723

No

26(66.67%)

33(84.62%)

59(75.64%)

3

Education of children affected

Yes

14(35.90%)

21(53.85%)

35(44.87%)

0.059

0.484

0.191

1.204

No

25(64.10%)

18(46.15%)

43(55.13%)

4

Fear related COVID19

Yes

25(64.10%)

32(82.05%)

57(73.08%)

0.041*

0.395

0.131

1.121

No

14(35.90%)

7(17.95%)

21(26.92%)

5

The financial crisis arises in family

Yes

12(30.77%)

21(53.85%)

33(42.31%)

0.021*

0.385

0.148

0.973

No

27(69.23%)

18(46.15%)

45(57.69%)

6

Regular Physical activity affected

Yes

26(66.67%)

32(82.05%)

58(74.36%)

0.065

0.442

0.145

1.267

No

13(33.33%)

7(17.95%)

20(25.64%)

Covid 19 negative

7

Gender

Female

23(60.53%)

12(30.00%)

35(44.87%)

0.003*

3.515

1.382

9.275

Male

15(39.47%)

28(70.00%)

43(55.13%)

8

social behaviour changes noticed by society members

Yes

18(47.37%)

10(25.00%)

28(35.90%)

0.022*

2.664

1.024

7.189

No

20(52.63%)

30(75.00%)

50(64.10%)

9

Happy with Urbanization

Yes

22(57.89%)

33(82.50%)

55(70.51%)

0.009*

0.296

0.098

0.829

No

16(42.11%)

7(17.50%)

23(29.49%)

10

Fear of survival is in danger

Yes

14(36.84%)

8(20.00%)

22(28.21%)

0.054

2.307

0.834

6.677

No

24(63.16%)

32(80.00%)

56(71.79%)

11

fear of when someone visits you or you visit someone

Yes

16(42.11%)

7(17.50%)

23(29.49%)

0.009*

3.373

1.204

10.111

No

22(57.89%)

33(82.50%)

55(70.51%)

12

affect mentally most of the time

Yes

16(42.11%)

10(25.00%)

26(33.33%)

0.059

2.159

0.823

5.843

No

22(57.89%)

30(75.00%)

52(66.67%)

13

Education of children affected

Yes

24(63.16%)

19(47.50%)

43(55.13%)

0.087

1.879

0.757

4.748

No

14(36.84%)

21(52.50%)

35(44.87%)

14

Having a servant at home for daily housework

Yes

9(23.68%)

18(45.00%)

27(34.62%)

0.026*

0.384

0.139

1.012

No

29(76.32%)

22(55.00%)

51(65.38%)

15

Social Participation

Yes

22(57.89%)

33(82.50%)

55(70.51%)

0.009*

0.296

0.098

0.829

No

16(42.11%)

7(17.50%)

23(29.49%)

16

Type of Family

Extended

10(26.32%)

18(45.00%)

28(35.90%)

P- Value

Chi-square

Joint

10(26.32%)

1(2.50%)

11(14.10%)

0.007*

9.835

Nuclear

18(47.37%)

21(52.50%)

39(50.00%)

Table 3

Logistic regression COVID 19 positive and depression causes

Term (n=78)

Odds Ratio

95% C.I.

Coefficient

S.E.

Z-Statistic

P-Value

Lower

Upper

Fear of going to vegetable market or grocery store (Yes/No)

3.9548

1.2681

12.3337

1.3749

0.5803

2.3693

0.0178

Fear related COVID19 (Yes/No)

0.515

0.2706

0.9803

-0.6635

0.3284

-2.0204

0.0433

Final -2*Log-Likelihood:

101.172

Test

Statistic

D.F.

P-Value

Score

6.7884

2

0.0336

Likelihood Ratio

6.959

2

0.0308

Table 4

Logistic regression COVID 19 negative and depression causes

Term

Odds Ratio

95% C.I.

Coefficient

S.E.

Z-Statistic

P-Value

Lower

Upper

Gender (Male/Female)

0.3901

0.143

1.0627

-0.9413

0.511

-1.841

0.0656

Type of Family (Joint/Extended)

44.5819

4.357

456.149

3.7973

1.187

3.2005

0.0014

Type of Family (Nuclear/Extended)

3.3218

1.099

10.0391

1.2005

0.564

2.1275

0.0334

Social Participation (Yes/No)

0.3431

0.11

1.068

-1.0699

0.579

-1.8464

0.0648

Final -2*Log-Likelihood:

85.1458

Test

Statistic

D.F.

P-Value

Score

19.8377

4

0.0005

Likelihood Ratio

22.9851

4

0.0001

Figure 1

COVID 19 positive and depression causes SHAP value

https://s3-us-west-2.amazonaws.com/typeset-prod-media-server/cc20a660-8aa5-4a3d-9c5b-54fd53f18e04image1.png
Figure 2

COVID 19 positive and depression causes SHAP value

https://s3-us-west-2.amazonaws.com/typeset-prod-media-server/cc20a660-8aa5-4a3d-9c5b-54fd53f18e04image2.png

Discussion

The present study aimed at identifying the prevalence of depression and associated causes leading to depression among the common public in a metropolitan city like Mumbai during the period of the COVID-19 pandemic. The prevalence of depression in the study was observed to be 49.35% which was higher compared to the previous studies which were ranging from 15.95% to 20.86%. 6, 7, 8, 9, 10 High economic burden, urbanization and expanded small-scale industries and a good number of the migratory population might attribute to this variation in prevalence in Mumbai. This also indicates various factors such as socio-demographic state, health-related risk, community and interpersonal factors also have a significant influence on the mental health of the people including depression.

The socio-demographic variables associated with depression status showed some interesting results. Taking gender into consideration, the prevalence of depression is more among females (63%) than males (39%) and this difference in prevalence is statistically significant when the chi-square test is applied (p= 0.002). The same variation is seen in COVID positive and negative participants. Attitude towards urbanization stays an important factor in mental health as people tend to adapt to their urban living setup in a metropolitan city like Mumbai. While analysing the attitude toward urbanization, the prevalence of depression is more among those who feel unhappy about urbanization (60%) than those who are happy with urbanization and this difference is statistically significant (p=0.047). The COVID-19 pandemic has left a greater impact on the economic survival of people especially, those who work for daily wages, small roadside shops, restaurants and labourers of small and middle-scale industries. Thus there existed a fear of survival and such participants who feared that their survival is in danger showed a higher prevalence of depression (63%) than others (45%) with a p-value of 0.026. social distancing is one of the well-intended interventions in breaking the chain of transmission which restricts people's mobility in highly crowded places and family celebrations. It was observed that people who fear visiting someone or being visited had a higher prevalence of depression (63%) with p=0.034. Also, joint families and families with higher budget expenditures also showed a higher prevalence of depression (Table 1).

Conclusion

As it is clearly evident from the foregoing discussion, the COVID-19 pandemic has brought havoc on both the physical and mental health of common people. The physical illness has led to significant fear among the public due to higher infectivity rate, lack of adequate admission facilities higher death tolls at peaks of the pandemic. While, the mental state has been disturbed due to fear of acquiring infection, poor neighbour interaction, and economic loss that affects daily living. But unfortunately, mental illness has not acquired as much attention and effort to combat it as the physical illness of COVID-19. The pandemic has brought out the pressing necessity of paying more attention to mental disorders which have been normally ignored in India, the fact which is substantiated by less than 2 per cent allocation of the national health budget to mental disorders altogether. Further analysis shows that people who stay alone, those with limited or no socialization, poor and unsettled and uneducated people have had to bear the brunt of the disease the most. The pandemic has also deeply and adversely affected the relationship of all hues resulting in the worsening of mental health prominently depression. Now the hour demands to pay more attention to mental disorders, particularly depression. Appropriate interventions and behaviour change communication between medical professionals and the common public has to be improvised. Policymakers should consider giving special attention to identifying mental health disorders in the community.

Source of Funding

None.

Conflict of Interest

None.

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